Tag: knee

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Musseling Up study finds post-menopausal knee pain solution

Musseling Up study finds post-menopausal knee pain solution
Andrew Stanley says he is excited by the findings of the study, and what it could mean for women’s health.

STEVE HUSSEY 850A/Nelson Mail

Andrew Stanley says he is excited by the conclusions of the analyze, and what it could mean for women’s well being.

Scientists have identified that Greenshell mussels’ anti-inflammatory features might reduce knee and joint pain in post-menopausal women.

A series of scientific trials termed ‘Musseling Up’ observed females who consistently took 3g of Sanford’s Greenshell mussel Perna Ultra powder experienced a decline in the biomarker that measures style 2 collagen breakdown for girls with knee and joint discomfort.

The exploration task was a partnership among Cawthron Institute, Sanford Ltd, Massey University and Plant and Food items Exploration, and got renewed funding from the High Price Nourishment Nationwide Science Problem.

Mussel powder has been found to reduce joint pain in post-menopausal women at Sanford’s new Bioactives centre.

Nelson Mail

Mussel powder has been discovered to lower joint ache in write-up-menopausal ladies at Sanford’s new Bioactives centre.

Andrew Stanley, common supervisor of innovation at Sanford, said the funding authorized the study to appear at what he known as MINK (mussels strengthening nimble knees).

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Stanley reported people today experienced prolonged acknowledged Greenshell mussels had wellbeing benefits, but they hadn’t been very well researched.

“We experienced plenty of proof that Greenshell mussel powders had been excellent for joints, and a good healthy as an anti-inflammatory,” Stanley said. But it was all anecdotal.

What they have been lacking was an actual study completed on individuals, who could report the impacts they felt right after having the supplement.

Lead scientist, Massey Professor Marlena Kruger said the trial results are pleasing and agreed Sanford’s mussel powder can effectively be used as a preventative treatment for people with knee pains.

David Wiltshire/Nelson Mail

Guide scientist, Massey Professor Marlena Kruger claimed the demo benefits are pleasing and agreed Sanford’s mussel powder can correctly be used as a preventative treatment method for people with knee pains.

Maryam Abshrini, Massey College doctoral college student, stated the demo had serious impacts on the gals who participated.

“Study individuals have been telling us the mussel supplements enabled them to carry out every day life pursuits with out soreness.”

Direct scientist Professor Marlena Kruger claimed she was “pleased and surprised” with the study final results. The mussel powder can be a preventative intervention therapy for persons with early signals of knee pain, she explained.

One particular of the participants, Kruger stated, preferred executing triathlons and observed that immediately after frequently taking the powder, recovery was a lot quicker.

The results of this clinical trial experienced been interesting, Stanley mentioned.

“It’s incredibly interesting to have great potent proof that supports what we have been stating for a very long time.”

Most of Sanford’s mussels come from the Marlborough region.

Nelson Mail

Most of Sanford’s mussels arrive from the Marlborough region.

Stanley said getting in a position to give prospects assurance in the product and how it could enable them was some thing the analyze opened up for Sanford.

The organization would now appear into new chances, and refine its analysis, for instance focusing on the knee joint, Stanley explained. In transform, Sanford could deliver more precise solutions for the industry.

Stanley explained the conclusions were a New Zealand accomplishment tale.

A lot of the science was accomplished at Sanford’s Bioactives centre in Marlborough, where the bulk of Sanford’s mussel provide arrived from.

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A digital application and augmented physician rounds reduce postoperative pain and opioid consumption after primary total knee replacement (TKR): a randomized clinical trial | BMC Medicine

A digital application and augmented physician rounds reduce postoperative pain and opioid consumption after primary total knee replacement (TKR): a randomized clinical trial | BMC Medicine

  • Vowles KE, McEntee ML, Julnes PS, Frohe T, Ney JP, van der Goes DN. Rates of opioid misuse, abuse, and addiction in chronic pain: a systematic review and data synthesis. Pain. 2015;156(4):569–76.

    Article 
    PubMed 

    Google Scholar     

  • Makary MA, Overton HN, Wang P. Overprescribing is major contributor to opioid crisis. BMJ. 2017;359:j4792.

    Article 
    PubMed 

    Google Scholar     

  • Hirschfeld DJ. Trump Declares Opioid Crisis a ‘Health Emergency’ Requests no Funds The New York Times; 2017.


    Google Scholar     

  • Hollmann MW, Rathmell JP, Lirk P. Optimal postoperative pain management: redefining the role for opioids. Lancet. 2019;393(10180):1483–5.

    Article 
    PubMed 

    Google Scholar     

  • Silva BM, Rodrigues JJ, de la Torre DI, Lopez-Coronado M, Saleem K. Mobile-health: A review of current state in 2015. J Biomed Inform. 2015;56:265–72.

    Article 
    PubMed 

    Google Scholar     

  • Bhavnani SP, Narula J, Sengupta PP. Mobile technology and the digitization of healthcare. Eur Heart J. 2016;37(18):1428–38.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • Brummett CM, Waljee JF, Goesling J, Moser S, Lin P, Englesbe MJ, et al. New Persistent Opioid Use After Minor and Major Surgical Procedures in US Adults. JAMA Surg. 2017;152(6):e170504.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • Hamnvik OR, Alford DP, Ryan CT, Hardesty IT, Drazen JM. NEJM Knowledge+ Pain Management and Opioids – A New Adaptive Learning Module. N Engl J Med. 2019;380(16):1576–7.

    Article 
    PubMed 

    Google Scholar     

  • Babu KM, Brent J, Juurlink DN. Prevention of Opioid Overdose. N Engl J Med. 2019;380(23):2246–55.

    Article 
    PubMed 

    Google Scholar     

  • Colloca L, Barsky AJ. Placebo and Nocebo Effects. N Engl J Med. 2020;382(6):554–61.

    Article 
    PubMed 
    CAS 

    Google Scholar     

  • Benedetti F. Placebo analgesia. Neurol Sci. 2006;27(2):100–2.

    Article 

    Google Scholar     

  • Colloca L, Lopiano L, Lanotte M, Benedetti F. Overt versus covert treatment for pain, anxiety, and Parkinson’s disease. Lancet Neurol. 2004;3(11):679–84.

    Article 
    PubMed 

    Google Scholar     

  • Hack TF, Degner LF, Parker PA, Team SC. The communication goals and needs of cancer patients: a review. Psychooncology. 2005;14(10):831–47.

    Article 
    PubMed 

    Google Scholar     

  • Del Re AC, Fluckiger C, Horvath AO, Symonds D, Wampold BE. Therapist effects in the therapeutic alliance-outcome relationship: a restricted-maximum likelihood meta-analysis. Clin Psychol Rev. 2012;32(7):642–9.

    Article 
    PubMed 

    Google Scholar     

  • Epstein R, Street RL. Patient-centered communication in cancer care: promoting healing and reducing suffering: National Cancer Institute. Bethesda: US Department of Health and Human Services, National Institutes of Health; 2007.


    Google Scholar     

  • Baker PN, van der Meulen JH, Lewsey J, Gregg PJ. The role of pain and function in determining patient satisfaction after total knee replacement. Data from the National Joint Registry for England and Wales. J Bone Joint Surg Br. 2007;89(7):893–900.

    Article 
    PubMed 
    CAS 

    Google Scholar     

  • World Health O. ICD-10 : international statistical classification of diseases and related health problems : tenth revision. 2nd ed. Geneva: World Health Organization; 2004.


    Google Scholar     

  • Breivik H, Borchgrevink PC, Allen SM, Rosseland LA, Romundstad L, Hals EK, et al. Assessment of pain. Br J Anaesth. 2008;101(1):17–24.

    Article 
    PubMed 
    CAS 

    Google Scholar     

  • Younger J, Gandhi V, Hubbard E, Mackey S. Development of the Stanford Expectations of Treatment Scale (SETS): a tool for measuring patient outcome expectancy in clinical trials. Clin Trials. 2012;9(6):767–76.

    Article 
    PubMed 

    Google Scholar     

  • Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods. 2009;41(4):1149–60.

    Article 
    PubMed 

    Google Scholar     

  • Booth RG, Strudwick G, McBride S, O’Connor S, Solano López AL. How the nursing profession should adapt for a digital future. BMJ. 2021;373:n1190.

    Article 
    PubMed Central 

    Google Scholar     

  • Fairbrother P, Ure J, Hanley J, McCloughan L, Denvir M, Sheikh A, et al. Telemonitoring for chronic heart failure: the views of patients and healthcare professionals – a qualitative study. J Clin Nurs. 2014;23(1-2):132–44.

    Article 
    PubMed 

    Google Scholar     

  • Barello S, Triberti S, Graffigna G, Libreri C, Serino S, Hibbard J, et al. eHealth for Patient Engagement: A Systematic Review. Front Psychol. 2015;6:2013.

    PubMed 

    Google Scholar     

  • Eaton L, Walsh C, Magnuson T, Schweitzer M, Lidor A, Nguyen H, et al. On-line bariatric surgery information session as effective as in-person information session. Surg Obes Relat Dis. 2012;8(2):225–9.

    Article 
    PubMed 

    Google Scholar     

  • Heikkinen K, Leino-Kilpi H, Vahlberg T, Salanterä S. Ambulatory orthopaedic surgery patients’ symptoms with two different patient education methods. Int J Orthop Trauma Nurs. 2012;16(1):13–20.

    Article 

    Google Scholar     

  • Matthew DA. The use of a computer website prior to scheduled surgery (a pilot study): impact on patient information, acquisition, anxiety level, and overall satisfaction with anesthesia care. AANA J. 2005;73(1):29.


    Google Scholar     

  • D’Haese PF, Pallavaram S, Li R, Remple MS, Kao C, Neimat JS, et al. CranialVault and its CRAVE tools: a clinical computer assistance system for deep brain stimulation (DBS) therapy. Med Image Anal. 2012;16(3):744–53.

    Article 
    PubMed 

    Google Scholar     

  • de Visser H, Watson MO, Salvado O, Passenger JD. Progress in virtual reality simulators for surgical training and certification. Med J Aust. 2011;194(4):S38–40.

    PubMed 

    Google Scholar     

  • Neuprez A, Neuprez AH, Kaux J-F, Kurth W, Daniel C, Thirion T, et al. Early Clinically Relevant Improvement in Quality of Life and Clinical Outcomes 1 Year Postsurgery in Patients with Knee and Hip Joint Arthroplasties. Cartilage. 2018;9(2):127–39.

    Article 
    PubMed 

    Google Scholar     

  • Klimek M, Büchele G, Rehm M, Beyersmann J, Günther KP, Brenner H, et al. Long-term mortality of patients with osteoarthritis after joint replacement: Prognostic value of pre-and postoperative pain and function. Athritis Care Res. 2021;0(0):1–7. https://doi.org/10.1002/acr.24808.

    Article 
    CAS 

    Google Scholar     

  • Kaptchuk TJ, Miller FG. Placebo Effects in Medicine. N Engl J Med. 2015;373(1):8–9.

    Article 
    PubMed 
    CAS 

    Google Scholar     

  • Amanzio M, Pollo A, Maggi G, Benedetti F. Response variability to analgesics: a role for non-specific activation of endogenous opioids. Pain. 2001;90(3):205–15.

    Article 
    PubMed 
    CAS 

    Google Scholar     

  • Bingel U, Wanigasekera V, Wiech K, Ni Mhuircheartaigh R, Lee MC, Ploner M, et al. The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil. Sci Transl Med. 2011;3(70):70ra14. https://doi.org/10.1126/scitranslmed.3001244.

    Article 
    PubMed 
    CAS 

    Google Scholar     

  • Kam-Hansen S, Jakubowski M, Kelley JM, Kirsch I, Hoaglin DC, Kaptchuk TJ, et al. Altered placebo and drug labeling changes the outcome of episodic migraine attacks. Sci Transl Med. 2014;6(218ra5).

  • Levine JD, Gordon NC. Influence of the method of drug administration on analgesic response. Nature. 1984;312(5996):755–6.

    Article 
    PubMed 
    CAS 

    Google Scholar     

  • Moore RA, Cai N, Skljarevski V, Tolle TR. Duloxetine use in chronic painful conditions–individual patient data responder analysis. Eur J Pain. 2014;18(1):67–75.

    Article 
    PubMed 
    CAS 

    Google Scholar     

  • Rief W, Nestoriuc Y, Weiss S, Welzel E, Barsky AJ, Hofmann SG. Meta-analysis of the placebo response in antidepressant trials. J Affect Disord. 2009;118(1-3):1–8.

    Article 
    PubMed 
    CAS 

    Google Scholar     

  • Colloca L. The Placebo Effect in Pain Therapies. Annu Rev Pharmacol Toxicol. 2019;59:191–211.

    Article 
    PubMed 
    CAS 

    Google Scholar     

  • Elsenbruch S, Kotsis V, Benson S, Rosenberger C, Reidick D, Schedlowski M, et al. Neural mechanisms mediating the effects of expectation in visceral placebo analgesia: an fMRI study in healthy placebo responders and nonresponders. Pain. 2012;153(2):382–90.

    Article 
    PubMed 

    Google Scholar     

  • Kaptchuk TJ, Friedlander E, Kelley JM, Sanchez MN, Kokkotou E, Singer JP, et al. Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS One. 2010;5(12):e15591.

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar     

  • Timmers T, Janssen L, Kool RB, Kremer JA. Educating Patients by Providing Timely Information Using Smartphone and Tablet Apps: Systematic Review. J Med Internet Res. 2020;22(4):e17342.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • Klinger R, Colloca L, Bingel U, Flor H. Placebo analgesia: clinical applications. Pain. 2014;155(6):1055–8.

    Article 
    PubMed 

    Google Scholar     

  • Colloca L, Jonas WB, Killen J, Miller FG, Shurtleff D. Reevaluating the placebo effect in medical practice. Z Psychol. 2014;222(3):124–7.

    PubMed 
    PubMed Central 

    Google Scholar     

  • Benedetti F. Placebo Effects. Understanding the mechanisms in health and disease. Oxford: Oxford University Press; 2014.

    Book 

    Google Scholar     

  • Colloca L, Miller FG. Harnessing the placebo effect: the need for translational research. Philos Trans R Soc Lond B Biol Sci. 2011;366(1572):1922–30.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • Enck P, Bingel U, Schedlowski M, Rief W. The placebo response in medicine: minimize, maximize or personalize? Nat Rev Drug Discov. 2013;12(3):191–204.

    Article 
    PubMed 
    CAS 

    Google Scholar     

  • Miller FG, Colloca L. The legitimacy of placebo treatments in clinical practice: evidence and ethics. Am J Bioeth. 2009;9(12):39–47.

    Article 
    PubMed 

    Google Scholar     

  • Schedlowski M, Enck P, Rief W, Bingel U. Neuro-Bio-Behavioral Mechanisms of Placebo and Nocebo Responses: Implications for Clinical Trials and Clinical Practice. Pharmacol Rev. 2015;67(3):697–730.

    Article 
    PubMed 

    Google Scholar     

  • Crum A, Zuckerman B. Changing Mindsets to Enhance Treatment Effectiveness. JAMA. 2017;317(20):2063–4.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • Price DD, Finniss DG, Benedetti F. A comprehensive review of the placebo effect: recent advances and current thought. Annu Rev Psychol. 2008;59:565–90.

    Article 
    PubMed 

    Google Scholar     

  • Finniss DG, Benedetti F. Mechanisms of the placebo response and their impact on clinical trials and clinical practice. Pain. 2005;114(1-2):3–6.

    Article 
    PubMed 

    Google Scholar     

  • Colloca L, Finniss D. Nocebo effects, patient-clinician communication, and therapeutic outcomes. JAMA. 2012;307(6):567–8.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • Colloca L. How do placebo effects and patient-clinician relationships influence behaviors and clinical outcomes? Pain Rep. 2019;4(3):e758.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • Ashton-James CE, Forouzanfar T, Costa D. The contribution of patients’ presurgery perceptions of surgeon attributes to the experience of trust and pain during third molar surgery. Pain Rep. 2019;4(3):e754.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • Henry SG, Matthias MS. Patient-Clinician Communication About Pain: A Conceptual Model and Narrative Review. Pain Med. 2018;19(11):2154–65.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • Volkow ND, Collins FS. The Role of Science in Addressing the Opioid Crisis. N Engl J Med. 2017;377(4):391–4.

    Article 
    PubMed 

    Google Scholar     

  • White AG, Birnbaum HG, Mareva MN, Daher M, Vallow S, Schein J, et al. Direct costs of opioid abuse in an insured population in the United States. J Manag Care Pharm. 2005;11(6):469–79.

    Article 
    PubMed 

    Google Scholar     

  • Wolford ML, Palso K, Bercovitz A. Hospitalization for total hip replacement among inpatients aged 45 and over: United States, 2000-1010: US Department of Health and Human Services, Centers for Disease Control and …; 2015.

  • Arthrose K-IR. Gesundheitsberichterstattung des Bundes. Berlin: RKI; 2013.


    Google Scholar     

  • Darley JM, Fazio RH. Expectancy confirmation processes arising in the social interaction sequence. Am Psychol. 1980;35(10):867–81.

    Article 

    Google Scholar     

  • Von Korff M, Ormel J, Keefe FJ, Dworkin SF. Grading the severity of chronic pain. Pain. 1992;50(2):133–49.

    Article 

    Google Scholar     

  • Klinger R, Krug F, Goßmann M, Damzog U, Dahme B, Bruch H-P. Das perioperative Schmerz- und Befindlichkeitsinventar: Ein Fragebogen zur Erfassung der perioperativen Lebensqualität. Der Schmerz. 1999;13:86.


    Google Scholar     

  • Flor H, Rudy TE, Birbaumer N, Streit B, Schugens MM. The applicability of the West Haven-Yale multidimensional pain inventory in German-speaking countries. Data on the reliability and validity of the MPI-D. Schmerz. 1990;4(2):82–7.

    Article 
    PubMed 
    CAS 

    Google Scholar     

  • Lowe B, Wahl I, Rose M, Spitzer C, Glaesmer H, Wingenfeld K, et al. A 4-item measure of depression and anxiety: validation and standardization of the Patient Health Questionnaire-4 (PHQ-4) in the general population. J Affect Disord. 2010;122(1-2):86–95.

    Article 
    PubMed 

    Google Scholar     

  • Lequesne MG. The algofunctional indices for hip and knee osteoarthritis. J Rheumatol. 1997;24(4):779–81.

    PubMed 
    CAS 

    Google Scholar     

  • Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175–91.

    Article 
    PubMed 

    Google Scholar     

  • Beswick AD, Wylde V, Gooberman-Hill R, Blom A, Dieppe P. What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? A systematic review of prospective studies in unselected patients. BMJ Open. 2012;2(1):e000435.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar     

  • Kim SS, Kaplowitz S, Johnston MV. The effects of physician empathy on patient satisfaction and compliance. Eval Health Prof. 2004;27(3):237–51.

    Article 
    PubMed 
    CAS 

    Google Scholar     

  • Sim I. Mobile Devices and Health. N Engl J Med. 2019;381(10):956–68.

    Article 
    PubMed 

    Google Scholar     

  • Bortz J, Schuster C. Statistik für Human-und Sozialwissenschaftler: Limitierte Sonderausgabe. Berlin: Springer-Verlag; 2011.


    Google Scholar     

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    Steroid use for knee osteoarthritis may make it worse, studies say

    Steroid use for knee osteoarthritis may make it worse, studies say



    CNN
     — 

    A common therapy for some arthritis discomfort might actually be making the issue worse, in accordance to two new scientific tests.

    “Knee osteoarthritis is one particular of the most chronic, degenerative and progressive disorders, with an believed incidence of 800,000 sufferers each and every calendar year in the US alone,” reported guide writer of just one of the experiments, Dr. Upasana Bharadwaj.

    Osteoarthritis is a popular kind of arthritis where by the cartilage inside a joint breaks down around time and the bones close to it alter, acquiring worse around time, in accordance to the US Facilities for Condition Management and Prevention.

    At the very least 10{35112b74ca1a6bc4decb6697edde3f9edcc1b44915f2ccb9995df8df6b4364bc} of the clients in the research applied injections to take care of the discomfort, included Bharadwaj, who is a postdoctoral investigate fellow in the office of radiology at the College of California San Francisco’s College of Medicine. Two of individuals discomfort administration injectables are corticosteroids, the additional widespread of the two, and hyaluronic acid.

    The reports, which ended up presented at the yearly conference of the Radiological Culture of North The usa, utilized both radiograph or MRI images to keep track of the development of osteoarthritis in the knees of clients. Some of people individuals didn’t obtain any remedy and other folks received corticosteroid or hyaluronic acid injections, in accordance to the research.

    Both of those papers showed a statistically considerable maximize in progression of degenerative variations in knee cartilage above two many years in men and women that had corticosteroid injections in contrast with all those who experienced hyaluronic acid or no injections, in accordance to the study authors.

    Nevertheless, just because the visuals may possibly search even worse does not always indicate that the individuals are sensation a lot more soreness, mentioned Azad Darbandi, lead author of the other study.

    “You may well see that the knee looks poor on a radiograph, but the affected person could not be possessing worse signs or symptoms,” extra Darbandi, a researcher and health-related college student at the Chicago Healthcare School of Rosalind Franklin College of Drugs and Science.

    The scientific tests spotlight a discussion in the osteoarthritis scientific community about the function of changes in the composition of the joint. Presently, ache is the principally recognized symptom, reported Jason Kim, the Arthritis Foundation’s vice president of osteoarthritis investigation. Kim was not included in both analyze.

    The takeaway from the experiments is that corticosteroids really should be administered with caution for osteoarthritis soreness.

    Hyaluronic acid injections may perhaps be a promising option for controlling agony but is much less utilized because there is significantly less research, and most patients have to pay out out of pocket, Darbandi said.

    “Perhaps hyaluronic acid injections have to have to be analyzed for discomfort management extra thoroughly,” he stated.

    Corticosteroids are a rapid way to get agony aid and regulate inflammation but may well not be a very good possibility for extensive-phrase treatment, Kim claimed. Repeated injections can place patients at chance for other troubles, these types of as bacterial infections since corticosteroids suppress your immune procedure, he reported.

    And some folks may not see major gain from possibly steroid or hyaluronic acid injections, Kim included.

    For a very long-term method, Kim advised constructing a reliable workforce of well being care providers, which include your principal care health practitioner, orthopedic expert, physical therapist, nutritionist and rheumatologist.

    It could be valuable to handle body weight and entire body mass index, or BMI, to increase metabolic results and lower general inflammation, Kim stated. It’s also vital to try to workout and be bodily energetic, he claimed, adding that going for walks has been tested to improve arthritis.