Hyperbaric oxygen therapy shows promise, concerns

Hyperbaric oxygen therapy shows promise, concerns

For the approximately 23 million People suffering from extended Covid symptoms, an assortment of alternatives assert to provide some aid — from stem-cell solutions and naturopathic drugs to an obscure approach termed “blood-washing” only offered in Cyprus.

Just one in specific seems promising for some: hyperbaric oxygen therapy. It consists of breathing 100{35112b74ca1a6bc4decb6697edde3f9edcc1b44915f2ccb9995df8df6b4364bc} pure oxygen — up to a few occasions better than air’s standard oxygen amounts — in a pressurized chamber to empower the body to repair service cognitive and physical injury.

Some prolonged Covid individuals swear by the treatment, with 1 describing it to CNBC Make It as a “total activity changer.”

“It felt like I was practically human again,” says Danielle Gillan, a Lake Nona, Florida, resident who completed a few months of the therapy previous yr after battling debilitating indicators like memory loss, confusion and blurred vision.

But hyperbaric oxygen therapy’s results in dealing with very long Covid appears to be largely anecdotal — with limited details on why it works, how helpful it is, how extended its therapeutic results previous, regardless of whether it alleviates some indicators better than some others or if it carries unforeseen penalties.

Which is a enormous stumbling block for lots of healthcare gurus, who caution versus viewing it as a common solution for extensive Covid. It is really an expensive guess to make, too: The remedy, when used to deal with prolonged Covid, is only accessible at private amenities, some of which demand far more than $50,000 for the knowledge.

“We’re utilizing a remedy that’s intricate and not thoroughly understood to treat a medical affliction that is also new and elaborate,” says Dr. Venita Chandra, a vascular operation clinical professor at Stanford University. “The level of challenge that Covid brought onto culture has remaining people today achieving for nearly anything, but a lot much more knowledge is required just before this gets to be a effectively-founded remedy for lengthy Covid.”

How hyperbaric oxygen treatment works 

Hyperbaric oxygen remedy is only new when it will come to prolonged Covid: The U.S. Food stuff and Drug Administration has previously cleared it for issues like decompression illness, carbon monoxide poisoning and radiation injuries.

In pressurized professional medical-grade chambers, clients alternate among respiratory pure oxygen by a mask and regular air. When you go from the former to the latter, your brain interprets the fall in stress as a absence of oxygen, states Dr. Mohammed Elamir, a health practitioner at The Villages, Florida-dependent Aviv Clinics.

That triggers stem mobile output and blood vessel growth in the mind, which assists the system repair service alone in a selection of techniques, Elamir says.

A patient and nurse in a hyperbaric oxygen remedy chamber.

Source: Aviv Clinics

The remedy is just not Fda-accepted for prolonged Covid, but that does not halt private facilities from giving it as a treatment plans. It only usually means coverage organizations cannot enable include the charge.

At Aviv, long Covid sufferers signal up for 40 to 60 two-hour sessions — when a working day, 5 times a week, for 8 to 12 weeks. The clinic prices $36,000 to $51,000 for individuals 40 to 60 classes, such as personalised care outside the house of chamber periods, Elamir claims: conferences with physiologists and neurologists, dietary plans, mind imaging and medical assessments.

Some people are medically ineligible, Elamir states — like all those with the latest ear surgical procedures, who could possibly struggle with individuals air stress drops. Most of the types who do get treated have documented enhanced very long Covid indicators, the clinic provides.

A lack of details leaves unanswered questions 

Lynette Milakovich, a retiree in The Villages, expert a vary of lengthy Covid indications prior to commencing hyperbaric oxygen remedy. She had sleeplessness, felt “electrical shocks” all above her system and skilled brain fog that made it difficult to approach and keep in mind points, between other signs and symptoms.

Just after finishing 3 months’ worthy of of sessions at Aviv in December 2022, Milakovich experienced advancements in her cognitive perform, breathing and sensitivity to light and sound, she says.

There is constrained info on how lengthy all those added benefits could very last, but Milakovich says she hopes to hold therapeutic put up-remedy in the coming months.

Lynette Milakovich

Supply: Lynette Milakovich

Some long Covid clients may well profit additional from the treatment method than other folks. That’s due to the fact a wide variety of fundamental physiological disorders — like persistent lung problems, for case in point — can “travel diverse manifestations of long Covid,” suggests Dr. Lucy Horton, an infectious disease doctor who established the very long Covid clinic at UC San Diego Health and fitness.

The only way to much better fully grasp the treatment’s opportunity rewards is by means of “more substantial and broader research,” Horton suggests.

Elamir details to a 2022 research from Tel Aviv University, which examined 72 very long Covid sufferers with cognitive indicators like brain fog that lasted for at minimum a few months. Half underwent hyperbaric oxygen treatment for two months, when the other served as a command team.

Patients in the first group reported minimized brain fog, improved memory and interest, extra power and much less suffering. People in the regulate group failed to report any sizeable advancements.

The research acknowledged its possess constraints: The sample dimension was “relatively small,” and scientists only noticed the treatment’s outcomes for a person to three weeks soon after each patient’s remaining session. Any extended-phrase gains or downsides remain to be viewed.

Clinics like Aviv are believers. The research will “certainly” direct other researchers to ensure these constructive results, an Aviv spokesperson states.

Why the new extensive Covid procedure is so highly-priced

Even if hyperbaric oxygen remedy proves effective, its cost is a huge barrier to entry — primarily when prolonged Covid indications make it tough to function 40 several hours for each 7 days.

Nora Lieberman, a gallery coordinator in Washington D.C., states she’s had hassle respiratory, exhaustion and cognitive impairments that make it difficult to total normal tasks. She compensated just about $3,000 for 10 periods at a Restore Hyper Wellness area in Richmond, Virginia, in June 2021.

The therapy was “reenergizing,” but she finally couldn’t pay for the advised quantity of sessions, she states. “For quite a few [Covid] lengthy haulers, like myself, financial independence is gone simply because we are not able to do the job complete-time.”

Her signs and symptoms returned right after she halted the therapy, she states. It really is unclear regardless of whether that would’ve happened if she’d been through her full allotment of classes.

For lots of [Covid] extended haulers, like myself, economic flexibility is long gone for the reason that we cannot work entire-time.

Some clinics defray costs for patients who are not able to shoulder the significant expenditure. Aviv, for example, presents hyperbaric oxygen therapy at lowered charge “to individuals who wouldn’t commonly have access to our slicing-edge program,” in accordance to its site.

The application requests tax and revenue files demonstrating a money incapability to pay back the clinic’s conventional charges.

But for most folks, it will only get less high-priced when insurance policies firms can protect some of the price, which hinges on Food and drug administration approval for treating extended Covid. “This is a thing we are pushing in direction of,” claims an Aviv spokesperson.

It would not take place with out constructive info rising from larger sized-scale studies, claims Dr. Jonathan Whiteson, an associate professor of rehabilitation medicine at NYU Langone Wellbeing.

A couple of ongoing scientific tests exist, but there is no concrete timeline for when they are going to generate info, Horton provides.

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Child psychologist: 6 extraordinary types of kids

Therapy by AI holds promise and challenges : Shots

Therapy by AI holds promise and challenges : Shots
Some companies and researchers think smart computers might eventually help with provider shortages in mental health, and some consumers are already turning to chatbots to build "emotional resilience."
Some companies and researchers think smart computers might eventually help with provider shortages in mental health, and some consumers are already turning to chatbots to build "emotional resilience."

Just a year ago, Chukurah Ali had fulfilled a dream of owning her own bakery — Coco’s Desserts in St. Louis, Mo. — which specialized in the sort of custom-made ornate wedding cakes often featured in baking show competitions. Ali, a single mom, supported her daughter and mother by baking recipes she learned from her beloved grandmother.

But last February, all that fell apart, after a car accident left Ali hobbled by injury, from head to knee. “I could barely talk, I could barely move,” she says, sobbing. “I felt like I was worthless because I could barely provide for my family.”

As darkness and depression engulfed Ali, help seemed out of reach; she couldn’t find an available therapist, nor could she get there without a car, or pay for it. She had no health insurance, after having to shut down her bakery.

So her orthopedist suggested a mental-health app called Wysa. Its chatbot-only service is free, though it also offers teletherapy services with a human for a fee ranging from $15 to $30 a week; that fee is sometimes covered by insurance. The chatbot, which Wysa co-founder Ramakant Vempati describes as a “friendly” and “empathetic” tool, asks questions like, “How are you feeling?” or “What’s bothering you?” The computer then analyzes the words and phrases in the answers to deliver supportive messages, or advice about managing chronic pain, for example, or grief — all served up from a database of responses that have been prewritten by a psychologist trained in cognitive behavioral therapy.

That is how Ali found herself on a new frontier of technology and mental health. Advances in artificial intelligence — such as Chat GPT — are increasingly being looked to as a way to help screen for, or support, people who dealing with isolation, or mild depression or anxiety. Human emotions are tracked, analyzed and responded to, using machine learning that tries to monitor a patient’s mood, or mimic a human therapist’s interactions with a patient. It’s an area garnering lots of interest, in part because of its potential to overcome the common kinds of financial and logistical barriers to care, such as those Ali faced.

Potential pitfalls and risks of chatbot therapy

There is, of course, still plenty of debate and skepticism about the capacity of machines to read or respond accurately to the whole spectrum of human emotion — and the potential pitfalls of when the approach fails. (Controversy flared up on social media recently over a canceled experiment involving chatbot-assisted therapeutic messages.)

“The hype and promise is way ahead of the research that shows its effectiveness,” says Serife Tekin, a philosophy professor and researcher in mental health ethics at the University of Texas San Antonio. Algorithms are still not at a point where they can mimic the complexities of human emotion, let alone emulate empathetic care, she says.

Tekin says there’s a risk that teenagers, for example, might attempt AI-driven therapy, find it lacking, then refuse the real thing with a human being. “My worry is they will turn away from other mental health interventions saying, ‘Oh well, I already tried this and it didn’t work,’ ” she says.

But proponents of chatbot therapy say the approach may also be the only realistic and affordable way to address a gaping worldwide need for more mental health care, at a time when there are simply not enough professionals to help all the people who could benefit.

Someone dealing with stress in a family relationship, for example, might benefit from a reminder to meditate. Or apps that encourage forms of journaling might boost a user’s confidence by pointing when out where they make progress.

Proponents call the chatbot a ‘guided self-help ally’

It’s best thought of as a “guided self-help ally,” says Athena Robinson, chief clinical officer for Woebot Health, an AI-driven chatbot service. “Woebot listens to the user’s inputs in the moment through text-based messaging to understand if they want to work on a particular problem,” Robinson says, then offers a variety of tools to choose from, based on methods scientifically proven to be effective.

Many people will not embrace opening up to a robot.

Chukurah Ali says it felt silly to her too, initially. “I’m like, ‘OK, I’m talking to a bot, it’s not gonna do nothing; I want to talk to a therapist,” Ali says, then adds, as if she still cannot believe it herself: “But that bot helped!”

At a practical level, she says, the chatbot was extremely easy and accessible. Confined to her bed, she could text it at 3 a.m.

“How are you feeling today?” the chatbot would ask.

“I’m not feeling it,” Ali says she sometimes would respond.

The chatbot would then suggest things that might soothe her, or take her mind off the pain — like deep breathing, listening to calming music, or trying a simple exercise she could do in bed. Ali says things the chatbot said reminded her of the in-person therapy she did years earlier. “It’s not a person, but, it makes you feel like it’s a person,” she says, “because it’s asking you all the right questions.”

Technology has gotten good at identifying and labeling emotions fairly accurately, based on motion and facial expressions, a person’s online activity, phrasing and vocal tone, says Rosalind Picard, director of MIT’s Affective Computing Research Group. “We know we can elicit the feeling that the AI cares for you,” she says. But, because all AI systems actually do is respond based on a series of inputs, people interacting with the systems often find that longer conversations ultimately feel empty, sterile and superficial.

While AI may not fully simulate one-on-one individual counseling, its proponents say there are plenty of other existing and future uses where it could be used to support or improve human counseling.

AI might improve mental health services in other ways

“What I’m talking about in terms of the future of AI is not just helping doctors and [health] systems to get better, but helping to do more prevention on the front end,” Picard says, by reading early signals of stress, for example, then offering suggestions to bolster a person’s resilience. Picard, for example, is looking at various ways technology might flag a patient’s worsening mood — using data collected from motion sensors on the body, activity on apps, or posts on social media.

Technology might also help improve the efficacy of treatment by notifying therapists when patients skip medications, or by keeping detailed notes about a patient’s tone or behavior during sessions.

Maybe the most controversial applications of AI in the therapy realm are the chatbots that interact directly with patients like Chukurah Ali.

What’s the risk?

Chatbots may not appeal to everyone, or could be misused or mistaken. Skeptics point to instances where computers misunderstood users, and generated potentially damaging messages.

But research also shows some people interacting with these chatbots actually prefer the machines; they feel less stigma in asking for help, knowing there’s no human at the other end.

Ali says that as odd as it might sound to some people, after nearly a year, she still relies on her chatbot.

“I think the most I talked to that bot was like 7 times a day,” she says, laughing. She says that rather than replacing her human health care providers, the chatbot has helped lift her spirits enough so she keeps those appointments. Because of the steady coaching by her chatbot, she says, she’s more likely to get up and go to a physical therapy appointment, instead of canceling it because she feels blue.

That’s precisely why Ali’s doctor, Washington University orthopedist Abby Cheng, suggested she use the app. Cheng treats physical ailments, but says almost always the mental health challenges that accompany those problems hold people back in recovery. Addressing the mental-health challenge, in turn, is complicated because patients often run into a lack of therapists, transportation, insurance, time or money, says Cheng, who is conducting her own studies based on patients’ use of the Wysa app.

“In order to address this huge mental health crisis we have in our nation — and even globally — I think digital treatments and AI can play a role in that, and at least fill some of that gap in the shortage of providers and resources that people have,” Cheng says.

Not meant for crisis intervention

But getting to such a future will require navigating thorny issues like the need for regulation, protecting patient privacy and issues of legal liability. Who bears responsibility if the technology goes wrong?

Many similar apps on the market, including those from Woebot or Pyx Health, repeatedly warn users that they are not designed to intervene in acute crisis situations. And even AI’s proponents argue computers aren’t ready, and may never be ready, to replace human therapists — especially for handling people in crisis.

“We have not reached a point where, in an affordable, scalable way, AI can understand every sort of response that a human might give, particularly those in crisis,” says Cindy Jordan, CEO of Pyx Health, which has an app designed to communicate with people who feel chronically lonely.

Jordan says Pyx’s goal is to broaden access to care — the service is now offered in 62 U.S. markets and is paid for by Medicaid and Medicare. But she also balances that against worries that the chatbot might respond to a suicidal person, ” ‘Oh, I’m sorry to hear that.’ Or worse, ‘I don’t understand you.’ ” That makes her nervous, she says, so as a backup, Pyx staffs a call center with people who call users when the system flags them as potentially in crisis.

Woebot, a text-based mental health service, warns users up front about the limitations of its service, and warnings that it should not be used for crisis intervention or management. If a user’s text indicates a severe problem, the service will refer patients to other therapeutic or emergency resources.

Cross-cultural research on effectiveness of chatbot therapy is still sparse

Athena Robinson, chief clinical officer for Woebot, says such disclosures are critical. Also, she says, “it is imperative that what’s available to the public is clinically and rigorously tested,” she says. Data using Woebot, she says, has been published in peer-reviewed scientific journals. And some of its applications, including for post-partum depression and substance use disorder, are part of ongoing clinical research studies. The company continues to test its products’ effectiveness in addressing mental health conditions for things like post-partum depression, or substance use disorder.

But in the U.S. and elsewhere, there is no clear regulatory approval process for such services before they go to market. (Last year Wysa did receive a designation that allows it to work with Food and Drug Administration on the further development of its product.)

It’s important that clinical studies — especially those that cut across different countries and ethnicities — continue to be done to hone the technology’s intelligence and its ability to read different cultures and personalities, says Aniket Bera, an associate professor of computer science at Purdue.

“Mental-health related problems are heavily individualized problems,” Bera says, yet the available data on chatbot therapy is heavily weighted toward white males. That bias, he says, makes the technology more likely to misunderstand cultural cues from people like him, who grew up in India, for example.

“I don’t know if it will ever be equal to an empathetic human,” Bera says, but “I guess that part of my life’s journey is to come close.”

And, in the meantime, for people like Chukurah Ali, the technology is already a welcome stand-in. She says she has recommended the Wysa app to many of her friends. She says she also finds herself passing along advice she’s picked up from the app, asking friends, “Oh, what you gonna do today to make you feel better? How about you try this today?”

It isn’t just the technology that is trying to act human, she says, and laughs. She’s now begun mimicking the technology.

Insomnia Medications Show Promise in Fighting Drug and Alcohol Addiction

Insomnia Medications Show Promise in Fighting Drug and Alcohol Addiction
Taking Prescription Medicine Concept

Drug and liquor dependancy is a serious and elaborate problem that impacts hundreds of thousands of people today globally. It is characterized by a solid and usually uncontrollable desire to use medicine or drink alcoholic beverages, even when undertaking so will cause destructive implications. Addiction is often accompanied by physical and psychological dependence, which can make it difficult to halt utilizing medicine or alcohol.

A research executed by Rutgers University uncovered that improvements in the mind can direct to a want for medicine and shown how specified insomnia medications may be able to avoid this habits.

Researchers at Rutgers College have found a potential biological method for drug and alcoholic beverages addiction and believe that that recent treatments for sleeplessness could most likely be utilized to minimize or reduce cravings.

An post not long ago revealed in the journal Biological Psychiatry discusses the results of scientists at the Rutgers Brain Wellbeing Institute and other institutions on the purpose of the orexin program in drug addiction. The orexin program, which regulates rest styles, reward pathways, and mood, has been identified to generate drug-looking for conduct. It has been observed that many drugs of abuse boost orexin output in both equally human and animal brains, and blocking this system can reverse habit in animals. In addition, a independent examine has proven that one of the 3 Food and drug administration-accredited insomnia remedies that block orexin can reduce opioid cravings in human topics.

“There’s even now a lot to discover about how orexin drives drug craving, but we know more than sufficient to justify testing orexin antagonists in medical trials as addiction therapies,” reported Gary Aston-Jones, coauthor of the review and director of the Brain Well being Institute. “We’re making use of for funding from the Countrywide Institutes of Wellness and seeking to employ the service of a medical professional-scientist with medical trial encounter to direct these endeavours.”

The review, which draws on a lot more than a 10 years of publications from scientists at Rutgers and peer establishments, suggests that orexin spurs drug craving and, consequently, enthusiasm to procure a drug.

Less than typical situation, lots of orexin-producing cells in the brain transform orexin manufacturing on and off in strategies that raise and lessen determination. These cells flip on when, e.g., men and women experience a restricted deadline and want to get work done and switch off at night to permit rest. Nonetheless, when folks grow to be addicted to opioids, cocaine, liquor and other substances, these cells maximize orexin production but no for a longer period convert it off. They keep on continuously, making significant concentrations of orexin that motivates one actions: getting an additional hit.

Managed research of mice, rats, zebrafish and other animals have permitted scientists to systematically look at just about every move in the approach. Postmortem evaluation of mind tissue from individuals who employed heroin demonstrates the same raise in the human orexin procedure that researchers have observed in addicted animals. As soon as brought on, this overactivity may well last endlessly – without a doubt, the analysis group noticed elevated orexin concentrations in cocaine-addicted rats that stayed sober for more than a quarter of their pure lifespan.

Earlier analysis into orexin’s snooze-blocking effects spurred the development of anti-orexin sleeplessness drugs, 3 of which have been authorised by the U.S. Food stuff and Drug Administration (Belsomra, Quviviq and Davigo). As orexin’s purpose in habit has emerged, scientists have tested these remedies as addiction remedies, mainly in animals. Investigate at Rutgers has located that reduced doses of one particular of these drugs can decrease drug-looking for habits in rats with out sedating them or impairing cognitive perform. In addition, a new review from Johns Hopkins College showed that this medicine can cut down cravings in folks detoxifying from opioids.

“There’s certainly no warranty orexin antagonists will effectively deal with addiction, but our analysis gives us superior purpose for hope,” reported Morgan James, coauthor of the overview and a professor of psychiatry at Rutgers Robert Wooden Johnson Clinical University. “And the need for helpful remedies is enormous. Overdose deaths have skyrocketed previous 100,000 a year and current procedure possibilities have limited efficacy.”

Reference: “Orexin Reserve: A Mechanistic Framework for the Purpose of Orexins (Hypocretins) in Addiction” by Morgan H. James and Gary Aston-Jones, 1 July 2022, Organic Psychiatry.
DOI: 10.1016/j.biopsych.2022.06.027