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Omicron variant BQ.1.1 found to be resistant to all monoclonal antibody treatments

Omicron variant BQ.1.1 found to be resistant to all monoclonal antibody treatments

Comprehensive resistance of Omicron sublineage B.Q.1.1 to neutralization by mAbs (A) Area of mutations (blue and crimson) in the spike proteins of SARS-CoV-2 lineages B.1, BA.1, and BA.4–5 (which are identical at the amino acid amount), BA.4.6, BA.2.75.2, BJ.1, and BQ.1.1 (numbered in accordance to the spike protein of SARS-CoV-2 Wuhan-Hu-01). Mutations that are exclusive to only one of the Omicron sublineages are highlighted in crimson and conserved mutations between Omicron sublineages are indicated beneath the sequences in eco-friendly. (B)…

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